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5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione
品牌:Adipogen
货号:CDX-P0110-M005 规格:5 mg 目录价:¥1330
货号:CDX-P0110-M010 规格:10 mg 目录价:¥2128
货号:CDX-P0110-M050 规格:50 mg 目录价:¥8512
产品详情
产品名称:
5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione
别名:
(Z)-5-(4-Propoxybenzylidene)thiazolidine-2,4-dione; SMI-16a
产品描述:
Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1alpha (68% inhibition of DYRK1alpha and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (<18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).
宿主来源:
Synthetic
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
263.3
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95% (HPLC)
CAS号:
587852-28-6
分子式:
C13H13NO3S
溶解度:
Soluble in DMSO.
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