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折扣/货期| 货号：501220 | 规格：96 wells | 目录价：￥14022 |
产品详情
产品名称:
Acylated Ghrelin (pig) EIA Kit
别名:
Acylated Ghrelin (pig) ELISA
产品描述:
Ghrelin discovered in 1999, is fast becoming an endocrinology target of the millennium. Ghrelin, identified in rat stomach as an endogenous ligand for the GH secretagogue receptor, is mainly produced in stomach, but has been demonstrated in many otther organs. In addition to GH-releasing properties and its orexant action, Ghrelin could act as an hormone having effects on gastric motility (similarity with the peptide hormone motilin), acidic secretion, cardiovascular action, antiproliferative effects, pancreatic and glucose metabolism function, sleep... Ghrelin gene raises to mRNA prepro-ghrelin of 117 amino acids. This precursor is processed into Ghrelin, 28 amino acids (human). Before being secreted, this peptide is octanoylated at Ser 3 by GOAT (Ghrelin Octanoyl Acyl Transferase). This step is essential for biological activity making GOAT a perfect target for drugs in feeding behaviour. Interestingly, the potential therapeutic importance of this hormone is not restricted to regulation of food intake but also in cachexia (related to cancer treatment, anorexia nervosa or ischemia) gastric motility and may be involved in osteoporosis, somatopause, infertility and ovulation induction, neurological disorders (Alcoholism, Post Traumatic Stress disorders...) and cardiovascular diseases. [Bertin Catalog No. A05401.96 wells]
靶标/特异性:
Unacylated Ghrelin (pig) <1%|Ghrelin (1-14) (human) <0.001%|Ghrelin (1-11) (rat) <0.001%|CRF (human, rat) <0.001%|Ghrelin (17-28) (human, rat) <0.001%|GHRF (human) <0.001%|Glucagon (human, rat) <0.001%|Insulin (human) <0.001%|Leptin (human) <0.001%|Motiline <0.001%|Somatostatine <0.001%
保存温度:
-20
运输温度:
-20
有效期:
180
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