货号:AG-40A-0180-C010 | 规格:10 ug | 目录价:¥3480 |
货号:AG-40A-0180-C050 | 规格:50 ug | 目录价:¥8280 |
产品详情
产品名称:
HES1 (human) (rec.) (His)
别名:
Hairy and Enhancer of Split 1; Transcription Factor HES-1; Class B Basic Helix-loop-helix Protein 39; bHLHb39; Hairy Homolog; Hairy-like Protein; HRY; hHL
产品描述:
bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.
宿主来源:
E. coli
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~35kDa (SDS-PAGE)
产品形式:
liquid
存储溶液:
Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>90% (SDS-PAGE)
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