血清素（5-羟色胺，5-HT）是一种存在于中枢神经系统、胃肠道和血液中的单胺，在神经传递、胃肠运动、止血和心血管完整性方面具有广泛的生理功能。现已发现七个亚类（5-HT 1-7）的5-羟色胺受体，其中大部分是含有七个跨膜结构域的GPCR家族成员，并且是几种抗抑郁药物的靶点。5-HT1亚类由五个高度同源的受体组成，通过G(i/o) alpha亚基偶联以抑制腺苷酸环化酶活性。5-HT1A在哺乳动物中的表达在控制情绪的中枢神经边缘通路中最强，包括海马体、背脊和隔膜的组织。血清素是用于监测各种物种的健康状况或评估行为障碍的关键生物标志物。
ENZO Serotonin ELISA kit是一种比色竞争法酶免疫检测试剂盒，可在3小时内得出结果。
w 高灵敏度，可检测低至0.293 ng/ml的血清素
w 标准品和样品不需要酰化
w 已在多种样本类型中得到验证
w 高通量，3小时内可得到结果，可检测多达39个样本（复孔）
产品信息
产品货号 | ADI-900-175 |
产品名称 | Serotonin ELISA kit（血清素ELISA试剂盒） |
规格 | 96 wells |
其他名称 | 5-HT, 5-hydroxytryptamine |
灵敏度 | 0.293 ng/ml |
检测范围 | 0.49 - 500 ng/ml |
检测时间 | 3 hours |
样本种属 | Species independent |
样本类型 | platelets, plasma, serum, and urine. Cited sample type includes culture supernatant. |
保存温度 | Store all components at -20°C |
试剂盒组分 | GxR IgG Microtiter plate, Conjugate, Antibody, Assay buffer, Wash buffer concentrate, Standard, pNpp Substrate, Stop solution |
部分产品引用文献
1. Associations of neurotransmitters and the gut microbiome with emotional distress in mixed type of irritable bowel syndrome: Z.A. Barandouzi, et al.; Sci. Rep. 12, 1648 (2022)
2. Enhanced presence of serotonin in nasal cavity after autologous stimulation: F. Salvinelli, et al.; Eur. Rev. Med. Pharmacol. Sci. 256, 2970 (2022)
3. Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields: E.D.D. Cerro, et al.; Environ. Health 21, 72 (2022)
4, Modulation of Intestinal Corticotropin-Releasing Hormone Signaling by the Herbal Preparation STW 5-II: Possible Mechanisms for Irritable Bowel Syndrome Management: M. Elbadawi, et al.; Pharmaceuticals (Basel) 15, 1121 (2022)
5. Phytochemical screening and effect of Viscum album L. on monoamine oxidase A and B activity and serotonin, dopamine and serotonin receptor 5-HTR1A levels in Galleria mellonealla (Lepidoptera): A. Szurpnicka, et al.; J. Ethnopharmacol. 298, 115604 (2022)
6. Telotristat ethyl reverses myxomatous changes in mice mitral valves: X. Wang, et al.; Front. Cardiovasc. Med. 9, 945672 (2022)
7. Airway basal stem cells generate distinct subpopulations of PNECs: H. Mou, et al.; Cell Rep. 35, 109011 (2021)
8. Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression: J. Obermanns, et al.; Eur. J. Neurosci. 53, 3476 (2021), Application(s): ELISA using human serum
9. Neuroprotective role of camphor against ciprofloxacin induced depression in rats: modulation of Nrf-2 and TLR4: A. Salama, et al.; Immunopharmacol. Immunotoxicol. 43, 309 (2021)
10. Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes: N. Nakatsuka, et al.; Mol. Psychiatry 26, 2753 (2021)
11. Serotonin involvement in okadaic acid-induced diarrhoea in vivo: M.C. Louzao, et al.; Arch. Toxicol. 95, 2797 (2021)
12. Coagulation Profiles of Pulmonary Arterial Hypertension Patients, Assessed by Non-Conventional Hemostatic Tests and Markers of Platelet Activation and Endothelial Dysfunction: E. Vrigkou, et al.; Diagnostics (Basel) 10, 758 (2020)
13. Effects on tactile transmission by serotonin transporter inhibitors at Merkel discs of mouse whisker hair follicles: W. Chang & J.G. Gu; Mol. Pain 16, 1744806920938237 (2020)
14. Perinatal androgens organize sex differences in mast cells and attenuate anaphylaxis severity into adulthood: E. Mackey, et al.; PNAS 117, 23751 (2020), Application(s): Lysed BMMCs (bone marrow-derived Mast Cells) supernatants
15. Platelet inhibition by ticagrelor is protective against diabetic nephropathy in mice: M. Uil, et al.; FASEB J. 34, 13750 (2020), Application(s): Mouse plasma
16. Unexpected effects of long-term treatment with acetylsalicylic acid on late phase of pulmonary metastasis in murine model of orthotopic breast cancer: M. Smeda, et al.; PLoS One 15, e0230520 (2020)
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