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PeproGMP Recombinant Human Heregulinbeta-1
品牌：PeproTech
货号：GMP100-03-100ug 规格：100ug 目录价：￥询价
货号：GMP100-03-1mg 规格：1mg 目录价：￥询价
货号：GMP100-03-50ug 规格：50ug 目录价：￥询价
产品详情
产品名称:
PeproGMP Recombinant Human Heregulinbeta-1
别名:
Neuregulin1 (NRG1-beta1), Neu differentiation factor (rat), HRG, HRG1-beta1, Breast cancer cell differentiation factor p45, ARIA (Acetylcholine, Receptor Inducing Activity), glial growth factor
产品描述:
Neuregulin/Heregulin is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-beta1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-beta1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Additional product information and specifications are provided on the Certificate of Analysis.
宿主来源:
E.coli
预期分子量:
7.5 kDa
产地:
美国
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