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SUMO1 (human) (rec.) (Rhodamine 110)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：SBB-PS0028-C050

规格：50 ug

目录价：￥4914

产品详情

产品名称:

SUMO1 (human) (rec.) (Rhodamine 110)

别名:

Small Ubiquitin-related Modifier 1; GAP-modifying Protein 1; SMT3C, SMT3H3, UBL1; Sentrin; Ubiquitin-homology Domain Protein PIC1

产品描述:

SUMO1 is a ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. This SUMO1 substrate is C-terminally derivatized with a bis-Gly-Rhodamine 110 fluorophore. The bis-Gly-Rh110 is quenched until the amide bond between the C-terminal glycine and the bis-Gly-Rh110 compound is hydrolyzed to mono-Gly-Rhodamine 110. The efficiency of quenching combined with the powerful signal upon hydrolysis yields a reagent with unparalleled signal-to-background. SUMO1-Rh110 can be used to study the deSUMOylating activity of hydrolases SENP1 and SENP2, or other deSUMOylating enzymes. The substrate activity of SUMO1-Rhodamine 110 was determined by measuring the SENP1 catalyzed release of unquenched mono-Gly-Rh110.

宿主来源:

E. coli

偶联:

Rhodamine

产品浓度:

Lot dependent.

保存温度:

-80°C

运输温度:

Dry Ice

预期分子量:

~12kDa