吉西他滨加顺铂(GP)化疗是鼻咽癌(NPC)的一种标准治疗方式。然而,治疗的机制尚不清楚。最近,中山大学科研团队在期刊《Nature Medicine》(IF=82.9)上发表题为“The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment.”的文章,使用单细胞RNA测序,对首次治疗和GP治疗后的NPC样本(n = 15对)的T细胞和B细胞受体测序匹配,结果显示GP化疗会激活先天样B细胞(ILB)主导的抗肿瘤免疫反应。化疗诱发的DNA片段激活了STING, 增加干扰素依赖途径在癌细胞中表达MHC Class I,并同时诱导 ILB通过Toll样受体9信号通路。对 germinal centers无效的化疗,ILB通过ICOSL–ICOS轴进一步扩大了follicular helper和helper type 1 T 细胞随后增强三级淋巴器官样结构中的细胞毒性T细胞。ILB频率是与3期临床试验中的接受GP化疗的NPC患者(NCT01872962,n = 139)总体无病生存率呈正相关。ILB频率可以作为GP和免疫疗法联合治疗(n = 380)以下治疗的NPC患者中作为有利结果的预测因子。该研究提供了GP化疗后肿瘤免疫微环境的高分辨率地图并发现B细胞为中心的抗肿瘤作用。研究还确定并验证了在NPC以全科医生为基础的治疗中ILB作为一个潜在的生物标志物可以改善病人管理。
本文中使用了欣博盛Human IFN-β ELISA kit检测了细胞培养上清中该蛋白的含量。
1.文章题目:The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment.
期 刊:Nature Medicine(影响因子:82.9)
发表时间:6 June 2023
作 者:Lv J, Wei Y, Yin J H, et al.
作者单位:中山大学
使用产品:Human IFN-β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37280275/
2.文章题目:Inhibition of Phosphoglycerate dehydrogenase induces ferroptosis and overcomes enzalutamide resistance in castration-resistant prostate cancer cells.
期 刊:Drug Resistance Updates(影响因子:24.3)
发表时间:14 June 2023
作 者:Wang J, Zeng L, Wu N, et al.
作者单位:南方医科大学
使用产品:Annexin V-FITC/PI apoptosis assay kit
https://www.sciencedirect.com/science/article/abs/pii/S1368764623000687
3.文章题目:A Hierarchical 3D Graft Printed with Nanoink for Functional Craniofacial Bone Restoration.
期 刊:Advanced Functional Materials(影响因子:19)
发表时间:6 June 2023
作 者:Shi Y, Shi J, Sun Y, et al.
作者单位:浙江大学
使用产品:Human BMP-2 ELISA kit
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202301099
4.文章题目:Engineered Oxygen Factories Synergize with STING Agonist to Remodel Tumor Microenvironment for Cancer Immunotherapy.
期 刊:Advanced Functional Materials(影响因子:19)
发表时间:19 June 2023
作 者:Zhang X, Yang Y, Li J, et al.
作者单位:上海交通大学
使用产品:Mouse IFN-γ and CXCL10 ELISA kits
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202300833
5.文章题目:Innovative design of minimal invasive biodegradable poly (glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration.
期 刊:Nature Communications(影响因子:16.6)
发表时间:30 June 2023
作 者:Wang L, Jin K, Li N, et al.
作者单位:北京航空航天大学
使用产品:Human SDF-1α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37391454/
6.文章题目:A cell-free tissue-engineered tracheal substitute with sequential cytokine release maintained airway opening in a rabbit tracheal full circumferential defect model.
期 刊:Biomaterials(影响因子:15.304)
发表时间:17 June 2023
作 者:Liu Y, Zheng K, Meng Z, et al.
作者单位:空军军医大学
使用产品:Human TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37352607/
7.文章题目:Self-Assembled Sulfated Hyaluronan Coating Modulates Transforming Growth Factor-Beta1 Penetration for Corneal Scarring Alleviation.
期 刊:ACS Applied Materials & Interfaces(影响因子:9.5)
发表时间:21 June 2023
作 者:Huang Y, Liu J, Sun X, et al.
作者单位:华南理工大学
使用产品:Human TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37344377/
8.文章题目:Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury.
期 刊:Journal of Neuroinflammation(影响因子:9.3)
发表时间:23 June 2023
作 者:Li J, Xu P, Hong Y, et al.
作者单位:南京大学
使用产品:Mouse IL-1β and IL-18 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37353794/
9.文章题目:Stapled peptide PROTAC induced significantly greater anti-PD-L1 effects than inhibitor in human cervical cancer cells.
期 刊:Frontiers in Immunology(影响因子:8.786)
发表时间:1 June 2023
作 者:Shi Y Y, Wang A J, Liu X L, et al.
作者单位:武汉大学
使用产品:Human TNF-α and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37325638/
10.文章题目:Long-term follow-up and exploration of the mechanism of stromal vascular fraction gel in chronic wounds.
期 刊:Stem Cell Research & Therapy(影响因子:8.079)
发表时间:19 June 2023
作 者:Cai Y, Zhang F, Feng J, et al.
作者单位:遵义医学院
使用产品:Human bFGF, EGF, TGF-β1 and VEGF ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37337292/
11.文章题目:NSAID–Au (I) Complexes Induce ROS-Driven DAMPs and Interpose Inflammation to Stimulate the Immune Response against Ovarian Cancer.
期 刊:Journal of Medicinal Chemistry(影响因子:7.3)
发表时间:8 June 2023
作 者:Xu Z, Lu Q, Shan M, et al.
作者单位:南京中医药大学
使用产品:Mouse TNF-α and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37291753/
12.文章题目:Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities.
期 刊:Acta Pharmacologica Sinica(影响因子:7.169)
发表时间:16 June 2023
作 者:Li H, Chen Y, Deng X, et al.
作者单位:沈阳药科大学
使用产品:Human IFN-γ ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37328649/
13.文章题目:Luteolin Enhances Transepithelial Sodium Transport in the Lung Alveolar Model: Integrating Network Pharmacology and Mechanism Study.
期 刊:International Journal of Molecular Sciences(影响因子:6.208)
发表时间:18 June 2023
作 者:Chen L, Yu T, Zhai Y, et al.
作者单位:中国医科大学
使用产品:Mouse IL-1β, IL-6 and TNF-α ELISA kits
样本类型:肺泡灌洗液
https://www.mdpi.com/1422-0067/24/12/10122
14.文章题目:TGF-β1 mediates tumor immunosuppression aggravating at the late stage post-high-light-dose photodynamic therapy.
期 刊:Cancer Immunology, Immunotherapy(影响因子:5.8)
发表时间:23 June 2023
作 者:Han L, Huang X, Zhao B, et al.
作者单位:中国药科大学
使用产品:Mouse IL-1β, TNF-α and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37351605/
15.文章题目:Recombinant Phaseolus vulgaris phytohemagglutinin L-form expressed in the Bacillus brevis exerts in vitro and in vivo anti-tumor activity through potentiation of apoptosis and immunomodulation.
期 刊:International Immunopharmacology(影响因子:5.714)
发表时间:1 June 2023
作 者:Wang P, Hu J, Min S, et al.
作者单位:四川大学
使用产品:Mouse IFN-γ ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37269742/
16.文章题目:MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-κB signaling pathway.
期 刊:International Immunopharmacology(影响因子:5.714)
发表时间:16 June 2023
作 者:Liu Z, Li Z, Yan G, et al.
作者单位:南方医科大学
使用产品:Human IL-17A ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37331297/
17.文章题目:Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway.
期 刊:International Immunopharmacology(影响因子:5.6)
发表时间:23 June 2023
作 者:Wu X, Xuan W, Yang X, et al.
作者单位:湖南省人民医院
使用产品:Mouse IL-1β ELISA kit
样本类型:肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/37356123/
18.文章题目:ZIM1 Combined with Hydrogel Inhibits Senescence of Primary PαS Cells during In Vitro Expansion.
期 刊:International Journal of Molecular Sciences(影响因子:5.6)
发表时间:5 June 2023
作 者:Tian Y, Hu M, Liu X, et al.
作者单位:北京大学口腔医院
使用产品:Mouse IL-8 ELISA kit
https://www.mdpi.com/1422-0067/24/11/9766
19.文章题目:Klebsiella pneumoniae outer membrane vesicles induce strong IL-8 expression via NF-κB activation in normal pulmonary bronchial cells.
期 刊:International Immunopharmacology(影响因子:5.6)
发表时间:22 June 2023
作 者:Li P, Peng T, Xiang T, et al.
作者单位:南昌大学
使用产品:Human IL-8 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37354781/
20.文章题目:Inhibition of IL-4/STAT6/IRF4 signaling reduces the epithelial-mesenchymal transition in eosinophilic chronic rhinosinusitis with nasal polyps.
期 刊:International Immunopharmacology(影响因子:5.6)
发表时间:27 June 2023
作 者:Chen J, Chen S, Gong G, et al.
作者单位:华中科技大学同济医学院
使用产品:Human TGF-β1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37385124/
21.文章题目: Sodium taurocholate hydrate inhibits influenza virus replication and suppresses influenza a Virus-triggered inflammation in vitro and in vivo.
期 刊:International Immunopharmacology(影响因子:5.6)
发表时间:29 June 2023
作 者:Sun X, Hu X, Zhang Q, et al.
作者单位:华中农业大学
使用产品:Mouse TNF-α, IL-1β, and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37392567/
22.文章题目:Microglia‐Mediated Neuroimmune Response Regulates Cardiac Remodeling After Myocardial Infarction.
期 刊:Journal of the American Heart Association(影响因子:5.4)
发表时间:15 June 2023
作 者:Wang M, Zhang J, Yin Z, et al.
作者单位:武汉大学人民医院
使用产品:Mouse TNF-α and IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37318008/
23.文章题目:Protective effect and underlying mechanism of muscone on acute cerebral ischemia-reperfusion injury in rats.
期 刊:Journal of Ethnopharmacology(影响因子:5.4)
发表时间:25 June 2023
作 者:Zhang P, You S, Ding X, et al.
作者单位:广东食品药品职业学院药学院
使用产品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37364767/
24.文章题目:Exploring the pharmacological mechanisms and key active ingredients of total flavonoids from Lamiophlomis rotata (Benth.) Kudo against rheumatoid arthritis based on multi-technology integrated network pharmacology.
期 刊:Journal of Ethnopharmacology(影响因子:5.4)
发表时间:27 June 2023
作 者:Zhan H, Chen R, Zhong M, et al.
作者单位:西南大学
使用产品:Mouse TNF-α and IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37385573/
25.文章题目:DsbA‐L deletion attenuates LPS‐induced acute kidney injury by modulating macrophage polarization.
期 刊:European Journal of Immunology(影响因子:5.4)
发表时间:28 June 2023
作 者:Cui P, Chen C, Cui Y, et al.
作者单位:广西大学
使用产品:Mouse IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37379419/
26.文章题目:Procoagulant effect of extracellular vesicles in patients after transcatheter aortic valve replacement or transcatheter aortic valve replacement with percutaneous coronary intervention.
期 刊:Journal of Thrombosis and Thrombolysis(影响因子:5.221)
发表时间:7 June 2023
作 者:Chi H, Shao Y, Xie F, et al.
作者单位:青岛大学
使用产品:Human sICAM-1 and VCAM-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37284999/
27.文章题目:Gastroprotective Effects of the Aqueous Extract of Finger Citron Pickled Products against Ethanol-Induced Gastric Damage: In Vitro and In Vivo Studies.
期 刊:Foods(影响因子:5.2)
发表时间:13 June 2023
作 者:Chen X, Yang D, Wang Q, et al.
作者单位:华南农业大学
使用产品:Rat TNF-α, IL-6, IL-10 and IL-1β ELISA kits
https://www.mdpi.com/2304-8158/12/12/2355
28.文章题目:Ciliated Cells Express a Novel Pattern of Brain-Derived Neurotrophic Factor in Allergic Rhinitis.
期 刊:Journal of Inflammation Research(影响因子:4.631)
发表时间:18 June 2023
作 者:Fang L, Li C H, Zhang Q, et al.
作者单位:山东大学
使用产品:Mouse IgE ELISA kit
样本类型:鼻灌洗液
https://www.tandfonline.com/doi/full/10.2147/JIR.S407368
29.文章题目:HSP90-Dependent Upregulation of EZH2 Promotes Hypoxia/Reoxygenation-Induced Pyroptosis by Inhibiting miR-22 in Endothelial Cells.
期 刊:Journal of Inflammation Research(影响因子:4.631)
发表时间:19 June 2023
作 者:Deng P, Hu H.
作者单位:南京医科大学
使用产品:Mouse IL-1β and IL-18 ELISA kits
https://www.tandfonline.com/doi/full/10.2147/JIR.S403531
30.文章题目: An X-ray inactivated vaccine against Pseudomonas aeruginosa Keratitis in mice.
期 刊:Vaccine(影响因子:4.169)
发表时间:21 June 2023
作 者:Jiang B, Luo Y, Yan N, et al.
作者单位:四川大学
使用产品:Mouse MIP-2, IL-10 and IL-1β(快速) ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37353454/
31.文章题目:Two Novel Adenovirus Vectors Mediated Differential Antibody Responses via Interferon-α and Natural Killer Cells.
期 刊:Microbiology Spectrum(影响因子:3.7)
发表时间:22 June 2023
作 者:Zou P, Zhang P, Deng Q, et al.
作者单位:南方医科大学
使用产品:Mouse IFN-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37347197/
32.文章题目: Isoliquiritigenin attenuates high glucose-induced proliferation, inflammation, and extracellular matrix deposition in glomerular mesangial cells by suppressing JAK2/STAT3 pathway.
期 刊:Naunyn-Schmiedeberg's Archives of Pharmacology(影响因子:3.6)
发表时间:27 June 2023
作 者:Zhang Z, Deng S, Shi Q.
作者单位:浙江工业大学
使用产品:Mouse TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37368032/
33.文章题目:A self-assembled nanoparticle vaccine based on pseudorabies virus glycoprotein D induces potent protective immunity against pseudorabies virus infection.
期 刊:Veterinary Microbiology(影响因子:3.246)
发表时间:5 June 2023
作 者:Ren X, Cao N, Tian L, et al.
作者单位:华中农业大学
使用产品:Mouse and porcine IFN-γ, IL-2, TNF-α, IL-4, and IL-10 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37327558/
34.文章题目:Immunogenic response of recombinant pseudorabies virus carrying B646L and B602L genes of African swine fever virus in mice.
期 刊:Veterinary Microbiology(影响因子:3.246)
发表时间:17 June 2023
作 者:Deng L, Gu S, Huang Y, et al.
作者单位:四川农业大学
使用产品:Mouse IL-4 and IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37348208/
35.文章题目:Notoginsenoside R1 Protects against Diabetic Nephropathy through TXNIP-NLRP3 Signaling Pathway.
期 刊:Clinical Complementary Medicine and Pharmacology(影响因子:3)
发表时间:11 June 2023
作 者:Zhang C, Yuan R, Li S, et al.
作者单位:广西中医药大学
使用产品:Mouse TNF-α ELISA kit
https://www.sciencedirect.com/science/article/pii/S2772371223000220
36.文章题目:Protective effects of Zishen Huoxue recipe against neuronal injury in the neurovascular unit of rats with vascular dementia by interfering with inflammatory cascade-induced pyroptosis.
期 刊:Neuropeptides(影响因子:2.9)
发表时间:26 June 2023
作 者:Yao T, Xie L, Xie Y, et al.
作者单位:湖南省中西医结合医院
使用产品:Mouse TNF-α and IL-6 ELISA kits
https://www.sciencedirect.com/science/article/abs/pii/S0143417923000392
37.文章题目:Knockout of Erbin promotes pyroptosis via regulating NLRP3/caspase-1/Gasdermin D pathway in sepsis-induced acute kidney injury
期 刊:Clinical and Experimental Nephrology(影响因子:2.3)
发表时间:13 June 2023
作 者:Liu Y, Fang Q, Ming T, et al.
作者单位:武汉大学
使用产品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37356123/
38.文章题目:Geniposide protected against cerebral ischemic injury through the anti-inflammatory effect via the NF-κB signaling pathway.
期 刊:Translational Neuroscience(影响因子:2.1)
发表时间:9 June 2023
作 者:Sun Q, Zhang X, Fan J, et al.
作者单位:河北医科大学
使用产品:Mouse TNF-α, IL-6 and IL-1β ELISA kits
样本类型:脑组织
https://pubmed.ncbi.nlm.nih.gov/37333874/
39.文章题目:Fucoxanthin Alleviates Lipopolysaccharide-Induced Inflammation and Immunosuppression in RAW264. 7 Macrophages.
期 刊:Doklady Biochemistry and Biophysics(影响因子:0.8)
发表时间:20 June 2023
作 者:Wang Z, Wang M, Lin M, et al.
作者单位:遵义医学院
使用产品:Mouse TNF-α and IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37340299/
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