TLR LIGANDS

TLR2 Agonists

CL401

PAM2C-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

1 ng - 10 µg/ml

500 µg

tlrl-c401

CL401 VacciGrade™

Preclinical grade CL401

VacciGrade™

20 - 50 µg/mouse

5 mg

vac-c401-5

CL413 - Adilipoline™

PAM2CK4-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

50 pg - 10 µg/ml

500 µg

tlrl-c413

CL413 VacciGrade™

Preclinical grade CL413

VacciGrade™

20 - 50 µg/mouse

5 mg

vac-c413-5

CL419

Pam2C-spermine compound

TLR2 +/ TLR4 -

1 ng - 100 µg/ml

500 µg

tlrl-c419

CL429

Pam2C-conjugated murabutide

TLR2 +/ TLR4 -

1 ng - 10 µg/ml

5 mg

tlrl-c429

CL429 VacciGrade™

Preclinical grade CL429

VacciGrade™

20 - 50 µg/mouse

5 mg

vac-c429

CL531

PAM2CK4-conjugated hydroxyadenine compound

TLR2 +/ TLR4 -

5 pg - 10 µg/ml

500 µg

tlrl-c531

CL572

Monoacyl-ethyl-cystein hydroxyadenine compound

TLR2 +/ TLR4 -

0.5 ng - 1 µg/ml

500 µg

tlrl-c572

FSL-1

Synthetic diacylated lipoprotein - TLR2/6

TLR2 +/ TLR4 -

1 - 100 ng/ml

100 µg

tlrl-fsl

HKBF

Heat Killed Bacteroides fragilis

TLR2 +/ TLR4 -

106 - 107 cells/m

109 cells

tlrl-hkbf

HKEB

Heat Killed Escherichia coli 0111:B4

TLR2 +/ TLR4 +

105 - 107 cells/ml

1010 cells

tlrl-hkeb

HKLM

Heat Killed Listeria monocytogenes

TLR2 +/ TLR4 -

107 - 108 cells/ml

1010 cells

tlrl-hklm

HKLR

Heat Killed Lactobacillus rhamnosus

TLR2 +/ TLR4 -

108 - 109 cells/ml

1010 cells

tlrl-hklr

HKMT

Heat Killed Mycobacterium tuberculosis

TLR2 +/ TLR4 -

100 ng - 10 µg/ml

10 mg

50 mg

tlrl-hkmt-1

tlrl-hkmt-5

HKPA

Heat Killed Pseudomonas aeruginosa

TLR2 +/ TLR4 -

105 - 107 cells/ml

1010 cells

tlrl-hkpa

HKSA

Heat Killed Staphylococcus aureus

TLR2 +/ TLR4 -

106 - 108 cells/ml

1010 cells

tlrl-hksa

HKSE

Heat Killed Staphylococcus epidermidis

TLR2 +/ TLR4 -

107 - 109 cells/ml

1010 cells

tlrl-hkse

HKSP

Heat Killed Streptococcus pneumoniae

TLR2 +/ TLR4 -

107 - 109 cells/ml

1010 cells

tlrl-hksp

HKST

Heat Killed Salmonella typhimurium

TLR2 +/ TLR4 +

104 - 109 cells/ml

1010 cells

tlrl-hkst

LPS-PG

Standard Lipopolysaccharide from P. gingivalis

TLR2 +/ TLR4 +

10 ng - 10 mg/ml

1 mg

tlrl-pglps

LTA-BS

Lipoteichoic acid from Bacillus subtilis

TLR2 +/ TLR4 +

100 ng - 1 µg/ml

5 mg

tlrl-lta

LTA-SA

Lipoteichoic acid from S. aureus

TLR2 +/ TLR4 +

100 ng - 1 µg/ml

5 mg

tlrl-slta

LTA-SA Purified

Purified lipoteichoic acid from S. aureus

TLR2 +/ TLR4 -

1 ng - 1 µg/ml

5 mg

tlrl-pslta

Pam2CSK4

Synthetic diacylated lipoprotein - TLR2(6)

TLR2 +/ TLR4 -

1 - 100 ng/ml

1 mg

tlrl-pm2s-1

Pam3CSK4

Synthetic triacylated lipoprotein - TLR1/2

TLR2 +/ TLR4 -

1 - 300 ng/ml

1 mg

tlrl-pms

Pam3CSK4 Biotin

Biotinylated Pam3CSK4

TLR2 +/ TLR4 -

10 - 300 ng/ml

50 µg

tlrl-bpms

Pam3CSK4 Rhodamine

Rhodamine-labeled Pam3CSK4

TLR2 +/ TLR4 -

1 - 300 ng/ml

50 µg

tlrl-rpms

Pam3CSK4 VacciGrade™

Preclinical grade Pam3CSK4

VacciGrade™

2 - 20 µg/mouse

1 mg

vac-pms

PGN-BS

Peptidoglycan from B. subtilis

TLR2 +/ TLR4 -

1 - 10 µg/ml

5 mg

tlrl-pgnb3

PGN-EB

Peptidoglycan from E. coli 0111:B4

TLR2 +/ TLR4 +

1 - 10 µg/ml

1 mg

tlrl-pgneb

PGN-EK

Peptidoglycan from E. coli K12

TLR2 +/ TLR4 +

1 - 10 µg/ml

1 mg

tlrl-pgnek

PGN-SA

Peptidoglycan from S. aureus

TLR2 +/ TLR4 -

0.1 - 10 µg/ml

5 mg

tlrl-pgns2

Zymosan

Cell wall preparation of S. cerevisiae

TLR2 +/ TLR4 -

1-10 µg/ml

100 mg

tlrl-zyn