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折扣/货期| 货号：39608 | 规格：250 µg | 目录价：￥8386 |
产品详情
产品名称:
2'3'-cGAMP-d8 (ammonium salt)
别名:
2'3'-Cyclic GMP-AMP-d8|Guanosine-Adenosine 2',3'-cyclic monophosphate-d8
产品描述:
2’3’-cGAMP-d8 is intended for use as an internal standard for the quantification of 2’3’-cGAMP (Item No. 19887) by GC- or LC-MS. 2’3’-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of dsDNA.{22401,22400,29220} It contains a non-canonical 2’5’-phosphodiester bond and binds tightly to the adapter protein stimulator of interferon genes (STING) with a Kd value of 3.79 nM, which is significantly lower than that observed for 2’2’-cGAMP (Item No. 22419), 3’3’-cGAMP (Item No. 17966), cyclic di-GMP (Item No. 17144), and 3’2’-cGAMP (Kds = 0.287, 1.04, 1.21, and 1.61 µM, respectively).{29220} It is a potent inducer of IFN-β mRNA expression with an EC50 value of 19.4 nM in L929 cells.{29220}
保存温度:
-20
运输温度:
-20
预期分子量:
716.5
产品形式:
A 1:1 solution in acetonitrile:water
有效期:
1095
纯度:
≥99% deuterated forms (d1-d8)
分子式:
C20H14D8N10O13P2 • 2NH4
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