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折扣/货期| 货号：IAX-200-021-3005 | 规格：3 x 5 mg | 目录价：￥6776 |
| 货号：IAX-200-021-M002 | 规格：2 mg | 目录价：￥1792 |
| 货号：IAX-200-021-M005 | 规格：5 mg | 目录价：￥2492 |
产品详情
产品名称:
Polyinosinic-polycytidylic acid [Poly(I:C)] Endotoxin-free (sterile)
别名:
Polyinosinic-polycytidylic acid, potassium salt (poly (I:C))
产品描述:
Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. Toll-like receptor 3 (TLR3), melanoma differentiation-associated gene 5 (MDA5), and retinoic acid-inducible gene-I (RIG-I), all sensors of double-stranded RNA (dsRNA) are potent inducers of antiviral activity. dsRNA sensor activation -e.g. by poly (I:C)- induces pro-inflammatory TNF-alpha and antiviral IFN-beta, but can also enhance the expression of pro-apoptotic proteins. Recently, poly (I:C)-induced cell death recently gained considerable attention as a tool to study the 'Ripoptosome' or 'Necrosome' complex, a novel intracellular signaling complex, thought to induce regulated necrosis, also called 'Necroptosis'.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
High molecular weight (>1.5kb).
产品形式:
solid
存储溶液:
Lyophilized. Sterile.
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>99%
生物活性:
Activates TLR3, MDA5/Helicard and RIG-I. Optimal working concentration depends upon target receptor accessibility, number, density, as well as cell type, and therefore needs to be determined for each application. Recommended concentration range: in vitro: 0.5-10µg/ml; in vivo: 5mg/kg.
内毒素水平:
<0.002EU/µg
CAS号:
31852-29-6
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