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折扣/货期| 货号：41072-100 µg | 规格：100 µg | 目录价：￥11522 |
| 货号：41072 | 规格：500 µg | 目录价：￥39326 |
产品详情
产品名称:
NR5A1 (C247S, C412S mutant; human, recombinant)
别名:
Ad4BP|Adrenal 4-binding Protein|Fushi Tarazu Factor Homolog 1|Nuclear Receptor Subfamily 5 Group A Member 1|SF-1|Steroidogenic Factor 1
产品描述:
Nuclear receptor subfamily 5 group A member 1 (NR5A1) is a nuclear receptor and member of fushi tarazu factor 1 subfamily of nuclear proteins.{15009,72431} NR5A1 monomers are composed of a hinge region, corepressor or coactivator binding site, a DNA-binding domain, and a hydrophobic ligand-binding domain, which can associate with different types of lipids, such as phosphatidylcholine, phosphatidylethanolamine, or phosphatidylglycerol, to activate steroidogenic gene expression.{15009,72431,72432} Additional post-translational modifications, including phosphorylation, acetylation, and SUMOylation, are necessary for coactivator or corepressor binding and transcriptional activity or repression, respectively.{15009} NR5A1 is critical in embryonic and pubescent sexual organ development and is expressed in the testes, ovaries, hypothalamus, and spleen, as well as pituitary and adrenal glands.{72431,72433} Mutations in NR5A1 are associated with low testosterone levels, androgyny, male infertility, malformed testes, ovarian dysfunction, and adrenal insufficiency.{72433,72434,72435} Cayman’s NR5A1 (C247S, C412S mutant; human, recombinant) protein consists of 243 amino acids and has a calculated molecular weight of 31.01 kDa.
保存温度:
-80
运输温度:
-80
产品形式:
20 mM Tris-HCl, pH 8.5, with 1 mM TCEP and 150 mM sodium chloride
有效期:
365
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