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折扣/货期| 货号：41075-100 µg | 规格：100 µg | 目录价：￥36302 |
| 货号：41075 | 规格：500 µg | 目录价：￥132258 |
产品详情
产品名称:
TEAD3 Cofactor-Binding Domain (human, recombinant)
别名:
TEA Domain Family Member 3|TEA Domain Transcription Factor 3|TEA Domain-containing Factor 1|TEF-5|Transcriptional Enhancer Factor 5
产品描述:
TEA domain transcription factor 3 (TEAD3) is a transcription factor and member of the TEA domain-containing family of transcription factors.{51833} It is composed of an N-terminal TEA DNA-binding domain, a hydrophobic proline-rich domain, and a C-terminal cofactor-binding domain (CBD), which binds tafazzin (TAZ) or YES-associated transcriptional regulator (YAP), or vestigial-like proteins (VGLLs), and is involved in TAZ-, YAP-, or VGLL-dependent transcription of genes in the Hippo signaling pathway, which regulates embryonic and organ development, proliferation, and cell death.{51835,51833} TEAD3 associates with VGLL3 to regulate growth and differentiation in primary mouse myoblasts and primary mouse myotubes.{51836} The tertiary structure and function of TEAD3 require C-terminal palmitoylation at residue 371.{51834} Increased tumor levels of TEAD3 are associated with decreased survival time, increased liver metastases, and reduced time of disease-free survival in patients with pancreatic ductal adenocarcinoma (PDAC).{51837} Cayman's TEAD3 Cofactor-Binding Domain (human, recombinant) protein consists of 219 amino acids, has a calculated molecular weight of 28.5 kDa, and is depalmitoylated at cysteine 371.
保存温度:
-80
运输温度:
-80
有效期:
365
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