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折扣/货期| 货号：38570 | 规格：700 µg | 目录价：￥2506 |
产品详情
产品名称:
TNP-GTP (sodium salt)
别名:
TNP-Guanosine 5'-triphosphate
产品描述:
TNP-GTP is a fluorescent derivative of the energy substrate for protein synthesis and gluconeogenesis, guanosine 5'-triphosphate (GTP; Item No. 16060).{67412} It displays an emission maximum of 552 nm upon excitation at 410 nm in water, with fluorescence increasing in intensity and shifting to 544 and 532 nm in 40 and 80% N,N-dimethylformamide, respectively, which is less polar than water.{67412} TNP-GTP is an inhibitor of glutamate dehydrogenase (Ki = 2.7 μM). When bound to glutamate dehydrogenase, the fluorescence intensity of TNP-GTP is increased and the emission shifts from 552 to 545 nm, an effect that can be blocked by addition of GTP. TNP-GTP is an antagonist of the purinergic P2X2 and P2X2/3 receptors (IC50s = 0.4 and 1.2 nM, respectively).{36447} It also selectively inhibits rat soluble guanylyl cyclase (sGC; Ki = 11 nM) over bovine liver glutamate dehydrogenase (GDH; Ki = 2.7 µM) and the calmodulin-dependent B. pertussis adenylyl cyclase (AC) toxin (Kis = 20 and 320 µM in the presence of manganese or magnesium, respectively).{67413,67412,65691}
保存温度:
-80
运输温度:
-80
预期分子量:
822.2
产品形式:
A solution in water
有效期:
730
纯度:
≥95%
分子式:
C16H13N8O20P3 • 4Na
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