瘦素(Leptin)是由ob基因编码、在脂肪组织中生成的一种脂肪代谢调控产物，在代谢和调控体重等方面发挥重要作用。它通过下丘脑中的瘦素受体发出信号，降低食欲，增加能量消耗。在外周组织中，瘦素能拮抗胰岛素信号传导，增加脂肪酸氧化，减少胰岛β细胞的胰岛素分泌，并促进生育。它在脂肪细胞中的表达可以被其他脂肪因子如IL-6（刺激）和TNF-α（抑制）以旁分泌方式调节。瘦素缺乏的小鼠表现出严重的胰岛素抵抗、肥胖和生育能力下降，所有这些都可以通过外源性瘦素给药而逆转。
● 灵敏：精确定量，可检测到最低23.4 pg/mL瘦素
● 方便：所有试剂保存在4°C
● 快速：仅需3小时就可获得39个样本的重复结果
● 预包被板和即用型试剂为您节省实验时间
产品信息
| 产品货号 | ADI-900-028A |
产品名称 | Leptin (human), ELISA kit（人瘦素ELISA试剂盒） |
规格 | 96 wells |
灵敏度 | 23.4 pg/ml |
检测范围 | 31.3 - 2,000 pg/ml |
检测时间 | 3 hours |
样本种属 | Human |
样本类型 | culture supernatants, plasma, and serum |
保存温度 | +4°C |
试剂盒组分 | Microtiter plate, Standard, Antibody, Conjugate, Assay buffer 17, TMB Substrate, Stop solution 2, Wash buffer concentrate |
部分产品引用文献
1. Leptin favors Th17/Treg cell subsets imbalance associated with allergic asthma severity: C.M. Vollmer, et al.; Clin. Transl. Allergy 12, e12153 (2022)
2. Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques: R. Rehman, et al.; Pak. J. Med. Sci. 34, 342 (2018), Application(s): ELISA using human serum
3. Neck circumference is associated with non-traditional cardiovascular risk factors in individuals at low-to-moderate cardiovascular risk: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): B. Almeida-Pititto, et al.; Diabetol. Metab. Syndr. 10, 82 (2018)
4. Comparison of the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus: G. Derosa, et al.; Hypertens. Res. 38, 690 (2015), Application(s): ELISA
5. Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension: M. Tellechea, et al.; Sci. Rep. 5, 7869 (2015), Application(s): ELISA
6. The Impact of LEP G-2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a Mexican Mestizo Population: E. Chavarria-Avila, et al.; BioMed Res. Int. 2015, 539408 (2015), Application(s): ELISA using human serum
7.Association between obesity-related adipokines and colorectal cancer: A case-control study and meta-analysis: R. K. Joshi, et al.; World J. Gastroenterol. 20, 7941 (2014)
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