爱游戏ayx(中国)官方网站,爱游戏app官方网站

您好,欢迎光临爱游戏ayx(中国)官方网站商城!
服务热线:400 680 0892
新闻资讯 News

BioXcell 新品推荐:InVivoMAb anti-mouse CD28单克隆抗体

2021-04-29
浏览次数: 37

InVivoMAb anti-mouse CD28单克隆抗体


研发背景

D665单克隆抗体可与小鼠CD28反应。CD28T细胞中关键的共刺激受体,同时也是Ig超家族成员之一,其主要由胸腺细胞、大部分外周血T细胞和NK细胞表达。CD28CD80 (B7-1)CD86 (B7-2)的受体。通过CD28信号传导可诱导IL-2IL-2受体表达和T细胞增殖。D665抗体是一种CD28超激动剂,在多种小鼠疾病模型中常用来诱导Treg细胞在体内的扩增。


产品信息

克隆号(Clone

D665

同种型(Isotype

Mouse IgG1

免疫原(Immunogen

A20 cells expressing mouse CD28 and a recombinant mouse CD28-Ig fusion protein

应用(Reported Applications

in vivo T cell stimulation/activation

in vitro T cell stimulation/activation

形式(Formulation

PBS, pH 7.0

Contains no stabilizers or preservatives

内毒素(Endotoxin

<2EU/mg (<0.002EU/μg)

Determined by LAL gel clotting assay

纯度(Purity

>95%

Determined by SDS-PAGE

无菌(Sterility

0.2 μM filtered

纯化(Purification

Protein G

分子量(Molecular Weight

150 kDa

储存(Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.


订购详情

产品名称

货号

规格

InVivoMAb anti-mouse CD28

BE0328

1MG,5MG,25MG,50MG,100MG


参考文献

Schmidt, T., et al. (2016). 'Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris.' Exp Dermatol 25(4): 293-298.

Win, S. J., et al. (2016). 'In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice.' Eur J Immunol 46(5): 1193-1202. 

Schuhmann, M. K., et al. (2015). 'CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke.' J Cereb Blood Flow Metab 35(1): 6-10.

Dennehy, K. M., et al. (2006). 'Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses.' J Immunol 176(10): 5725-5729. 



详情请咨询 BioXcell 中国授权代理-爱游戏ayx(中国)官方网站

全国服务热线: 4006-800-892            邮箱: market@hnyazd.com
深圳: 0755-26755892      北京: 010-88594029      上海: 021-34613729          
广州:18024516375        香港: 852-69410778
代理品牌网站: www.nbs-bio.com
自主品牌网站: www.neobiosescience.net
糖型分析网站:www.glycan-analysis.com 


分享到:
关注欣博盛公众号
Copyright ©2021 - 2023 深圳爱游戏ayx(中国)官方网站有限公司
  网站地图
犀牛云提供企业云服务
爱游戏ayx(中国)官方网站