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折扣/货期| 货号：32858-1 mg | 规格：1 mg | 目录价：￥49356 |
| 货号：32858-100 µg | 规格：100 µg | 目录价：￥8460 |
| 货号：32858 | 规格：20 µg | 目录价：￥3528 |
产品详情
产品名称:
CCL5/RANTES (human, recombinant)
别名:
C-C Motif Chemokine Ligand 5|Regulated Upon Activation, Normally T Expressed and Secreted|SIS-δ|T Cell-specific Protein P288|T Cell-specific Protein RANTES|TCP288
产品描述:
Chemokine (C-C motif) ligand 5 (CCL5), also known as RANTES, is a pro-inflammatory chemokine and member of the CC subfamily of chemokines.{57372} It is composed of an unstructured N-terminal region, a flexible loop, a 310-helix, three strands of an antiparallel β-sheet, and a single C-terminal α helix.{57373} It is expressed in T cells, platelets, macrophages, tubular epithelial cells, synovial fibroblasts, and endothelial cells, as well as some tumor cells.{57372} It functions as a monomer or various oligomers and interacts with the G protein-coupled receptors (GPCRs) chemokine (C-C motif) receptor 1 (CCR1), CCR3, CCR4, CCR5, and GPR75 to activate cell signaling in an oligomerization state-dependent manner. It also interacts with the non-signaling receptors ACKR1, ACKR2, and CCRL2. CCL5 functions as a chemoattractant of immune cells that predominantly express CCR5, such as activated T cells and monocytes, as well as those expressing CCR1 and CCR3, including macrophages and eosinophils, respectively.{57374} Production of CCL5 is induced in response to viral infections, including HIV, rhinoviruses, respiratory syncytial virus (RSV), coronaviruses, and influenza.{57375} CCL5 expression positively correlates with disease progression in patients with breast cancer.{57372} Cayman's CCL5/RANTES (human, recombinant) protein consists of 69 amino acids and has a calculated molecular weight of 8 kDa.
宿主来源:
E. coli
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile PBS, pH 7.4
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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