货号:40252-50 µg | 规格:50 µg | 目录价:¥5364 |
货号:40252 | 规格:500 µg | 目录价:¥34866 |
产品详情
产品名称:
Coagulation Factor X (human, recombinant)
别名:
Factor 10|Factor X|FX|Stuart Factor|Stuart-Prower Factor|Thrombokinase
产品描述:
Coagulation Factor X is a vitamin K-dependent plasma serine protease involved in the intrinsic, extrinsic, and common pathways of the blood coagulation cascade.{72150,52856} It is composed of an N-terminal light chain that contains a signal sequence, a propeptide, carboxylated glutamic acid residues (Gla domain), and two EGF domains and a C-terminal heavy chain that contains the activation peptide and a chymotrypsin-like catalytic domain.{72150} Factor X is produced as an inactive precursor, which is activated to Factor Xa following signal peptide cleavage, glycosylation, and further cleavage by the Factor VIIIa-IXa or tissue factor-FVIIa complexes of the intrinsic or extrinsic pathways, respectively. Factor Xa, in complex with Factor Va, converts prothrombin to thrombin. Factor Xa also cleaves severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as surface glycoprotein, and prevents SARS-CoV-2 viral entry in vitro, and Factor X levels are increased in the lungs of patients with COVID-19.{72151} Knockout of F10, the gene encoding Factor X, in mice induces embryonic lethality and fatal internal bleeding of surviving neonates.{72152} Mutations in F10 result in Factor X deficiency, a rare bleeding disorder characterized by CNS and gastrointestinal bleeding, as well as hemarthroses and hematomas.{72150} Cayman’s Coagulation Factor X (human, recombinant) protein consists of 468 amino acids, has a calculated molecular weight of 52.8 kDa, and a predicted N-terminus of Asn32 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular masses are 48 and 22 kDa, corresponding to the cleaved heavy and light chains, respectively, due to glycosylation.
宿主来源:
Insect cells
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile 50 mM Tris, pH 8.0, 100 mM sodium chloride, and 10% glycerol
有效期:
365
纯度:
≥97% estimated by SDS-PAGE
上一个:TNFSF8/CD30 Ligand Extracellular Domain (human, recombinant)
下一个:GLP-1R (human, recombinant; aa 24-145) (Fc-tagged)
您可能感兴趣的产品
Human Tau (K18) protein, mutant P301L (Pre-formed Fibrils)
货号:GTX17675-pro-S
Human alpha Synuclein protein (active, Pre-Formed Fibrils)
货号:GTX17669-pro-S
Human alpha Synuclein protein (monomer)
货号:GTX17666-pro-S
Human Tau (K18) protein, mutant P301L (monomer)
货号:GTX17673-pro-S
Mouse alpha Synuclein protein (active, monomer)
货号:GTX17670-pro-S
Human alpha Synuclein protein (active, monomer)
货号:GTX17668-pro-S
Human alpha Synuclein protein (Pre-Formed Fibrils)
货号:GTX17667-pro-S
Multiple Tags Positive Control (GST-DDDDK-V5-HSV-HA-T7-Myc-S)
货号:GTX130343-pro-L
促销活动
相关产品推荐