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折扣/货期| 货号：AG-40B-0160-C010 | 规格：10 ug | 目录价：￥3120 |
| 货号：AG-40B-0160-C100 | 规格：100 ug | 目录价：￥11400 |
产品详情
产品名称:
IL-33 (oxidation resistant) (human) (rec.) (untagged)
别名:
IL-33 (human) (C208S/C232S Mutant); Interleukin-33 (human) (C208S/C232S Mutant); IL-1F11; NF-HEV
产品描述:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3) / ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. IL-33 facilitates Treg expansion in vitro and in vivo. Recently, IL-33 has been involved in adipocyte differentiation. The biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by its oxidation (formation of two disulfide bridges), resulting in an extensive conformational change that disrupts the ST2 binding site. Mutations at amino acids C208S/C232S protect IL-33 from oxidation and increase its activity.
宿主来源:
E. coli
靶标/特异性:
Binds to human and mouse ST2.
产品浓度:
After reconstitution:for 10µg size: 0.1mg/mlfor 100µg size: 1mg/ml
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~17kDa (SDS-PAGE); Monomer (Size Exclusion Chromatography)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS + 1mM DTT
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
Activates human and mouse ST2-dependent NF-kappaB pathway. Activates in vivo Innate Lymphoid Cells 2 (ILC2) at 0.4µg /ml.
内毒素水平:
<0.01EU/µg purified protein (LAL test).
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下一个:IL-36alpha (aa 6-158) (human) (rec.) (untagged) MultiPack
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