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折扣/货期| 货号：GTX84989 | 规格：100μg | 目录价：￥6400 |
产品详情
产品名称:
PUMA antibody [10D4G7]
别名:
BCL2 binding component 3 , JFY-1 , JFY1 , PUMA
反应种属:
Human, Rat
宿主来源:
Mouse
实验应用:
ELISA, WB
同种型:
IgG1
免疫原:
Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
克隆性:
Monoclonal
克隆号:
10D4G7
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
阳性对照:
K562 Cell Lysate(GTX27911) , PUMA Recombinant Protein(GTX48024-PRO)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
产地:
美国
功能与背景:
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
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