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折扣/货期| 货号：33986-1 mg | 规格：1 mg | 目录价：￥31932 |
| 货号：33986 | 规格：100 µg | 目录价：￥4914 |
产品详情
产品名称:
PDGFRβ/CD140b Extracellular Domain (human, recombinant)
别名:
CD140 Antigen-like Family Member B|PDGFR-1|Platelet-derived Growth Factor Receptor 1|Platelet-derived Growth Factor Receptor β
产品描述:
PDGFRβ, also known as CD140b, is a type I transmembrane glycoprotein and receptor tyrosine kinase encoded by PDGFRB in humans.{54656} It is composed of five extracellular immunoglobulin-like (Ig-like) domains, a transmembrane domain, and an intracellular kinase domain. PDGFRβ is ubiquitously expressed and functions as a homodimer or a heterodimer with PDGFRα. Binding of the growth factor PDGF-BB or PDGF-DD to PDGFRβ promotes homodimerization, induces receptor autophosphorylation and a conformational change that facilitates access to the intracellular kinase domain, and intracellular signaling through multiple pathways, including ERK/MAPK, PI3K/AKT/mTOR, PLC/PKC, and JAK/STAT.{54656,54657,54658} Knockdown of Pdgfrb decreases the number of vascular smooth muscle cells, induces CNS-specific reduction in pericytes, and is postnatally lethal in mice. De novo mutations in PDGFRB have been found in patients with novel overgrowth syndrome.{54659} Cayman's PDGFRβ/CD140b Extracellular Domain (human, recombinant) protein can be used for binding assays. This protein consists of 510 amino acids, has a calculated molecular weight of 57.6 kDa, and a predicted N-terminus of Leu33 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 95 to 100 kDa due to glycosylation.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile PBS, pH 7.4
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
上一个:c-Kit/CD117 GNNK− Isoform Extracellular Domain (human, recombinant)
下一个:Notch1 (mouse, recombinant; aa 19-526)
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