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折扣/货期| 货号：120-30-100ug | 规格：100ug | 目录价：￥22138 |
| 货号：120-30-10ug | 规格：10ug | 目录价：￥2836 |
| 货号：120-30-1mg | 规格：1mg | 目录价：￥88652 |
| 货号：120-30-250ug | 规格：250ug | 目录价：￥38710 |
| 货号：120-30-2ug | 规格：2ug | 目录价：￥1163 |
| 货号：120-30-500ug | 规格：500ug | 目录价：￥57513 |
| 货号：120-30-50ug | 规格：50ug | 目录价：￥13268 |
产品详情
产品名称:
Recombinant Human DKK-1
别名:
Dickkopf-related protein-1, Dickkopf-1, SK
产品描述:
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Mature human DKK-1 expressed in HEK293 cells is a 35-40 kDa glycoprotein containing 235 amino acid residues. The calculated molecular weight of Recombinant Human DKK-1 expressed in HEK293 cells is 25.8 kDa.
宿主来源:
HEK293 cells
推荐稀释度:
请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
预期分子量:
25.8 kDa
产品形式:
Standard
产地:
美国
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