官网链接
折扣/货期| 货号：310-42-100ug | 规格：100ug | 目录价：￥5790 |
| 货号：310-42-10ug | 规格：10ug | 目录价：￥1169 |
| 货号：310-42-1mg | 规格：1mg | 目录价：￥25699 |
| 货号：310-42-250ug | 规格：250ug | 目录价：￥11215 |
| 货号：310-42-500ug | 规格：500ug | 目录价：￥16664 |
| 货号：310-42-50ug | 规格：50ug | 目录价：￥2910 |
产品详情
产品名称:
Recombinant Human TMIGD2/CD28H Fc
别名:
Transmembrane and immunoglobulin domain-containing protein 2, CD28 homolog, Immunoglobulin and proline-rich receptor 1 (IGPR-1)
产品描述:
Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2), or CD28H, is a type I costimulatory transmembrane receptor of the CD28 receptor family that functions as both an adhesion molecule and regulator of T cell function. TMIGD2 is constitutively expressed on naive T cells and NK cells, although expression is rapidly lost upon stimulation. Interaction with its ligand, B7-H7/HHLA2, co-stimulates T cell proliferation and differentiation, as well as increases cytokine production through the Akt pathway. TMIGD2 is also widely expressed on cells of epithelial and endothelial origin where it regulates cell morphology and cell-cell interaction, reduces cell migration and promotes angiogenesis. The cytoplasmic tail of TMIGD2 interacts with SH3-containing signaling molecules, such as SPIN90, CACNB2, BPAG1 and MIA, to modulate angiogenesis. CHO cell-derived Recombinant Human TMGID2/CD28H Fc is a glycosylated, disulfide-linked homodimer of 361-amino-acid-residues whose monomer consists of the 128-amino-acid extracellular domain fused to the 231-amino-acid length Fc portion of human IgG1 by two glycine residues. The calculated molecular weight of monomeric Recombinant TMIGD2/CD28H Fc is 40.1kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 55-60 kDa by SDS-PAGE analysis under reducing conditions.
宿主来源:
CHO cells
推荐稀释度:
请严格按照批次特异性说明书中Reconstitution部分指定的溶液溶解蛋白到推荐浓度
预期分子量:
40.1 kDa
产品形式:
Standard
产地:
美国
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